Discovery of a terpene synthase synthesizing a nearly non-flexible eunicellane reveals the basis of flexibility

Abstract Eunicellane diterpenoids, containing a typical 6,10-bicycle, are bioactive read more compounds widely present in marine corals, but rarely found in bacteria and plants.The intrinsic macrocycle exhibits innate structural flexibility resulting in dynamic conformational changes.However, the mechanisms controlling flexibility remain unknown.Th

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